Nucleosides and Nucleotides p. 1679 - 1693 (1994)
Update date:2022-09-26
Topics:
Van Draanen
Koszalka
A series of α-L-2',3'-dideoxy nucleosides was prepared as potential antiviral agents. The pyrimidine nucleosides were prepared by standard Vorbruggen coupling reactions. The purine analogues were prepared by enzymatic transfer of the dideoxy sugar from a pyrimidine to a purine base. These compounds were inactive against HIV-1, HBV, HSV-1 and -2, VZV, and HCMV.
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