Synthesis and biological evaluation of pyrimidine and purine α-L-2',3'- dideoxy nucleosides

Article abstract of DOI:10.1080/15257779408009473

A series of α-L-2',3'-dideoxy nucleosides was prepared as potential antiviral agents. The pyrimidine nucleosides were prepared by standard Vorbruggen coupling reactions. The purine analogues were prepared by enzymatic transfer of the dideoxy sugar from a pyrimidine to a purine base. These compounds were inactive against HIV-1, HBV, HSV-1 and -2, VZV, and HCMV.

Full text of DOI:10.1080/15257779408009473

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Nucleosides and Nucleotides
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Synthesis and Biological Evaluation of
Pyrimidine and Purine α-L-2′,3′-Dideoxy
Nucleosides
Naina A. Van Draanen a & George W. Koszalka a
a Division of Experimental Therapy , Burroughs Wellcome Co.
Research Triangle Park , NC, 27709
Published online: 24 Sep 2006.
To cite this article: Naina A. Van Draanen & George W. Koszalka (1994) Synthesis and Biological
Evaluation of Pyrimidine and Purine α-L-2′,3′-Dideoxy Nucleosides, Nucleosides and Nucleotides,
13:8, 1679-1693, DOI: 10.1080/15257779408009473
To link to this article: http://dx.doi.org/10.1080/15257779408009473
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