Structural requirements for hybridization at the 5′-position are different in α-l-LNA as compared to β-d-LNA

Article abstract of DOI:10.1016/j.bmcl.2011.11.012

The synthesis and biophysical evaluation of R and S-5′-Me-α-l- LNA nucleoside phosphoramidites and modified oligo-2′-deoxyribonucleotides is reported. Synthesis of the nucleoside phosphoramidites was accomplished in multi-gram quantities starting from dia