Formal Synthesis of (-)-Calcimycin (A-23187) via the 3-Methyl-γ-butyrolactone Approach

DOI: 10.1021/jo00275a019

Source and publish data:

Journal of Organic Chemistry p. 3347 - 3353 (1989)

Update date:2022-07-29

Topics:

Authors:

Ziegler, Frederick E.

Cain, William T.

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Article abstract of DOI:10.1021/jo00275a019

A synthesis of (+)-carboxylic acid 2a, which has been previously converted into the ionophore (-)-calcimycin (A-23187) and analogues thereof, is described.The synthesis involves the use of (S)-3-methyl-γ-butyrolactone (4) and both enantiomers of allylic alcohol 3a as the chiral entities.

Full text of DOI:10.1021/jo00275a019

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