Formal Synthesis of (-)-Calcimycin (A-23187) via the 3-Methyl-γ-butyrolactone Approach

Article abstract of DOI:10.1021/jo00275a019

A synthesis of (+)-carboxylic acid 2a, which has been previously converted into the ionophore (-)-calcimycin (A-23187) and analogues thereof, is described.The synthesis involves the use of (S)-3-methyl-γ-butyrolactone (4) and both enantiomers of allylic alcohol 3a as the chiral entities.