Synthesis and Biological Evaluation of 4,6-Diethyl-1,3,4,5-tetrahydropyranoindole-4-acetic Acid, an Isomer of Etodolac

DOI: 10.1021/jm00129a018

Source and publish data:

Journal of Medicinal Chemistry p. 2134 - 2137 (1989)

Update date:2022-08-05

Topics:

Authors:

Hughes, Philip

Virgilio, John De

Humber, Leslie G.

Chau, Thuy

Weichman, Barry

Neuman, Glen

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Article abstract of DOI:10.1021/jm00129a018

The synthesis of 4,6-diethyl-1,3,4,5-tetrahydropyrano<4,3-b>indole-4-acetic acid, an isomer of the antiinflammatory agent etodolac, is described.The compound was found to have an ED₅₀ of 3 mg/kg po in the rat curative adjuvant arthritis assay,

Full text of DOI:10.1021/jm00129a018

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