From carboxylic acids to the trifluoromethyl group using BrF3

DOI: 10.1016/j.tet.2010.03.045

Source and publish data:

Tetrahedron p. 3579 - 3582 (2010)

Update date:2022-09-26

Topics: Carboxylic Acids Trifluoromethyl group

Authors:

Cohen, Or

Mishani, Eyal

Rozen, Shlomo

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Article abstract of DOI:10.1016/j.tet.2010.03.045

Organic trifluoromethyl derivatives were made from aromatic and aliphatic carboxylic acids by transforming them first into the corresponding dithioesters followed by reaction with bromine trifluoride under mild conditions (0 °C, 2 min).

Full text of DOI:10.1016/j.tet.2010.03.045

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