DESIGN AND SYNTHESIS OF SUBSTRATE ANALOGS FOR THE INHIBITION OF DEHYDROQUINATE SYNTHASE

DOI: 10.1016/S0040-4039(00)99490-5

Source and publish data:

Tetrahedron Letters p. 1461 - 1464 (1989)

Update date:2022-08-04

Topics:

Authors:

Nikolaides, Nicholas

Ganem, Bruce

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)99490-5

The synthesis of two enantiomerically pure substrate analogs, designed as potential inhibitors of dehydroquinate synthase on the basis of the proposed mechanistic pathway for this enzyme, is reported.

Full text of DOI:10.1016/S0040-4039(00)99490-5

Products guided by the article

Product name:(1S,3R,4R)-1,3,4-Trihydroxy-5-methylene-cyclohexanecarboxylic acid

Cas No:123075-73-0

R&D Labs maybe for 123075-73-0

Mollt Biochem Co., Ltd(expird)

Contact:+86-21-38682181

Address:shanghai ,china
Henan Harvest Chem Co., Ltd

Contact:+86-371-86058576

Address:NO.32, Jingsan Road, Zhengzhou, China
PharmaResources(Kaiyuan)CO,.Ltd

Contact:+86-21-50720028

Address:No.3, Beihuan Road, Economic Development District, Kaiyuan City, Tieling City, Liaoning Province, China 112300
Zipont chem(wuhan）Tech co.，Ltd

Contact:+86-27-87587198

Address:wuhan
Chongqing Yawei Fine Chemical Co.,Ltd

Contact:0086-23-62849407

Address:Ziyou village, Nanquan town, Banan district, Chongqing China

Relevant to this article

Nonconventional versus conventional application of pseudo-first-order kinetics to fundamental organic reactions

Doi:10.1002/kin.20609
(2012)
A new synthetic methodology for the pyrrolidine ring

Doi:10.1055/s-0029-1219547
(2010)
Dynamic covalent chemistry of disulfides offers a highly efficient synthesis of diverse benzofused nitrogen-sulfur heterocycles in one pot

Doi:10.1021/cc100042v
(2010)
Synthesis of β- And γ-carbolinones via Pd-catalyzed direct dehydrogenative annulation (DDA) of indole-carboxamides with alkynes using air as the oxidant

Doi:10.1021/ol1007839
(2010)
Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: Structure-based drug design, synthesis, and biological evaluation

Doi:10.1016/j.bmc.2010.03.014
(2010)
Doi:10.1021/ja01636a031
(1954)

Article Doi