Design, synthesis, and biological evaluation of a novel class of γ-secretase modulators with pparγ activity

DOI: 10.1021/jm1003073

Source and publish data:

Journal of Medicinal Chemistry p. 4691 - 4700 (2010)

Update date:2022-08-04

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Authors:

Hieke, Martina

Ness, Julia

Steri, Ramona

Dittrich, Michaela

Greiner, Christine

Werz, Oliver

Baumann, Karlheinz

Schubert-Zsilavecz, Manfred

Weggen, Sascha

Zettl, Heiko

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Article abstract of DOI:10.1021/jm1003073

We present a novel class of dual modulators of γ-secretase and peroxisome proliferator-activated receptor γ (PPARγ) based on the structure of 2-(bis(phenethoxy)pyrimidine-2-ylthio)hexanoic acid 8 (IC ₅₀(Aβ42) = 22.8 μM, EC₅₀(PPARγ) =

Full text of DOI:10.1021/jm1003073

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Product name:ethyl 2-(4,6-bis(4-methoxyphenethoxy)pyrimidin-2-ylthio)hexanoate

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