Tetrahedron p. 173 - 182 (1991)
Update date:2022-08-03
Topics: Synthesis Asymmetric synthesis Chiral Catalyst Enantioselective Stereoselective Diastereoselective Reaction
Chen, Bang-Chi
Weismiller, Michael C.
Davis, Franklin A.
Boschelli, Diane
Empfield, James R.
Smith, Amos B.
An asymmetric synthesis of the highly oxygenated cyclopentanoid antibiotic (+)-kjellmanianone (1) has been achieved.The key step entailed enantioselective hydroxylation of the prochiral sodium enolate of β-keto ester 2 with the new, enatiomerically pure N-sulfonyloxaziridine 7b, affording 1 in 68.5percent ee (60percent yield).Possible transition state structures for the asymmetric oxidation are evaluated.
View MoreContact:+86-519-86623222
Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
Tianjin Hedong Red Cliff Chemical Reagent Factory
Contact:+86-022-84780548
Address:Li Ming Zhuang Gong Ye Yuan,Dongli District,Tianjin,China
Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.
Contact:--
Address:Huadian Pioneer Park, Huadian Township, Qihe County, Dezhou City, Shandong, P.R.China
Shanghai Yudiao Chemistry Technology Co.,Ltd
Contact:0086-18964703211
Address:Building NO.5, NO.218,Rongtian Road,ganxiang town,Jinshan District,shanghai,201518,china
wuxi leji biology technology co., LTD
website:http://www.lejibio.com/
Contact:18362718864
Address:The Nanyue Road No. 2, Yixing City, Jiangsu Province
Doi:10.1016/j.tetlet.2010.05.104
(2010)Doi:10.1021/om1002045
(2010)Doi:10.1039/c2md20332d
(2013)Doi:10.1002/ejoc.201000158
(2010)Doi:10.1016/j.bmc.2010.06.003
(2010)Doi:10.1016/j.bmc.2010.06.002
(2010)
