Journal of Fluorine Chemistry p. 131 - 144 (1989)
Update date:2022-08-05
Topics:
Fujii, Shozo
Maki, Yasuo
Kimoto, Hiroshi
The imidazole substitution of pentafluorobenzenes (C6F5R : R = CN, NO2, CO2C2H5, CHO, I, Br, Cl, H) occurred mainly at the para-position to R and corresponding 1-(4'-R-tetrafluorophenyl)imidazoles were obtained in good yields.The reactivity varied markedly with the substituents: nitro- or cyanopentafluorobenzene easily reacted at ambient temperature without any bases; however, methyl- or methoxypentafluorobenzene failed to react even at 100 degC in the presence of a strong base.
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