Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

Article abstract of DOI:10.1021/acs.jmedchem.9b00131

Gabazine, a γ-aminobutyric acid type A (GABA_A) receptor antagonist, has previously been reported to inhibit the binding of [³H]NCS-382, a representative ligand of the high-affinity binding site for the neuroactive substance γ-hydroxy