Synthesis and properties of myelopeptides possessing differentiating activity

DOI: 10.1134/S1068162010040035

Source and publish data:

Russian Journal of Bioorganic Chemistry p. 456 - 460 (2010)

Update date:2022-08-05

Topics:

Authors:

Fonina Fonina

Kudryavtseva

Bespalova

Efremov Efremov

Mikhailova

Kirilina

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Article abstract of DOI:10.1134/S1068162010040035

Bone marrow peptides Phe-Arg-Pro-Arg-Ile-Met-Thr-Pro (MP-4) and Val-Asp-Pro-Pro (MP-6) have been synthesized y the classical and solid-phase methods of peptide chemistry, and their differentiatingactivity has been studied on leukemia cell ines HL-60 and K-562. It has been shown that both peptides induce the terminal differentiation of leukemic blasts; however, their echanisms of action are different. Pleiades Publishing, Ltd., 2010.

Full text of DOI:10.1134/S1068162010040035

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