Novel 21-Aminosteroids That Inhibit Iron-Dependent Lipid Peroxidation and Protect against Central Nervous System Trauma

DOI: 10.1021/jm00166a010

Source and publish data:

Journal of Medicinal Chemistry p. 1145 - 1151 (1990)

Update date:2022-07-29

Topics:

Authors:

Jacobsen, E. Jon

McCall, John M.

Ayer, Donald E.

VanDoornik, Fred J.

Palmer, John R.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00166a010

A novel class of 21-aminosteroids has been developed.Compounds within this series are potent inhibitors of iron-dependent lipid peroxidation in rat brain homogenates with IC₅₀'s as low as 3 μM.Furthermore, selected members enhance early neurolo

Full text of DOI:10.1021/jm00166a010

Products guided by the article

Product name:Pregna-1,4,9(11)-triene-3,20-dione,21-[4-[5,6-bis(diethylamino)-2-pyridinyl]-1-piperazinyl]-16-methyl-, (16a)- (9CI)

Cas No:125173-71-9

R&D Labs maybe for 125173-71-9

Jiangxi Biochem Co.,Ltd

Contact:86-791-86629460

Address:1-6F, 118 Xinzhou road, Nanchang, Jiangxi, China
JIANGXI ZHANGFENG CHEMICAL CO., LTD.

Contact:+86-0799-3413066

Address:Xiyuan village, Xiabu Town, Xiangdong District
Taizhou Huading Chemical Co.,Ltd(expird)

Contact:+86-576-88583898

Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
NOVASYNCS CO., LTD

Contact:0512-63006287

Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
Jiangsu Jiuri Chemical Co.,Ltd.

Contact:+86-519-82118868

Address:Tianwang Town, Jurong City, Jiangsu Province, China

Relevant to this article

Oxorhenium mixed-ligand complexes with the 2,6-dimercaptomethylpyridine ligand. Crystal structure of [2,6-dimercaptomethylpyridinato][p-methoxy-benzenethiolato]oxorhenium(V)

Doi:10.1016/S0020-1693(00)00056-6
(2000)
Spectroscopic properties, structure and reactivity of [WCl(SnCl³)(CO)³(NCMe)²]

Doi:10.1016/S0277-5387(98)00123-5
(1998)
Synthesis of 1,1-difluoro-5-(1H-9-purinyl)-2-pentenylphosphonic acids and the related methano analogues. Remarkable effect of the nucleobases and the cyclopropane rings on inhibitory activity toward purine nucleoside phosphorylase

Doi:10.1016/S0968-0896(98)80023-0
(1998)
Doi:10.1021/ja01555a010
(1958)
Enantioselective synthesis of the 4-hydroxy buteneolide terminus of mucocin and related annonaceous acetogenins

Doi:10.1016/S0040-4039(98)02206-0
(1998)
Doi:10.1039/j39690000531
(1969)

Article Doi