Novel 21-Aminosteroids That Inhibit Iron-Dependent Lipid Peroxidation and Protect against Central Nervous System Trauma

DOI: 10.1021/jm00166a010

Source and publish data:

Journal of Medicinal Chemistry p. 1145 - 1151 (1990)

Update date:2022-07-29

Topics:

Authors:

Jacobsen, E. Jon

McCall, John M.

Ayer, Donald E.

VanDoornik, Fred J.

Palmer, John R.

et al. et al.

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Article abstract of DOI:10.1021/jm00166a010

A novel class of 21-aminosteroids has been developed.Compounds within this series are potent inhibitors of iron-dependent lipid peroxidation in rat brain homogenates with IC₅₀'s as low as 3 μM.Furthermore, selected members enhance early neurolo

Full text of DOI:10.1021/jm00166a010

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