Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I

DOI: 10.1021/jm000160l

Source and publish data:

Journal of Medicinal Chemistry p. 3981 - 3986 (2000)

Update date:2022-07-29

Topics:

Authors:

Kalsi Kalsi

Kavarana

Whalen Whalen

Hamilton

Creighton

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm000160l

Hydrophobic interactions play an important role in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active sites of human, yeast, and Pseudomonas putida glyoxalase I, as the log K(i) values for these mechanism-based competitive inhibitors de

Full text of DOI:10.1021/jm000160l

Products guided by the article

Product name:Carbamic acid, hydroxy-, 4-chlorophenyl ester

Cas No:125309-28-6

R&D Labs maybe for 125309-28-6

Hebei DaPeng Pharm & Chem Co., Ltd.

Contact:86-317-7298678,0576-88861898 88861908

Address:West Songmen Village, East Songmen Town, Wuqiao, Cangzhou, Hebei ,China
Nanjing Samwon International Limited

Contact:+86-25-84873444

Address:1108, BLDG B, New Century Plaza, No 1, South Taiping Rd.,
Shanghai Gsyn Chemical Co.,Ltd.

Contact:86-021-67158290

Address:86-021-67158291
Ningbo Inno Pharmchem Co., Ltd.

Contact:86-574-87319282

Address:6F-5,NO.163 RUIQING RD.,NINGBO 315000 CHINA
UNION PHARMPRO CO.,LTD

Contact:18710867521(wechat)

Address:Rm10516,Galaxy Tech Building #2,No.25 Tangyan Rd,Hi-Tech Zone,Xi'an, China

Relevant to this article

Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents

Doi:10.1016/j.ejmech.2019.111732
(2019)
Transition metal-free α-C(sp³)-H bond functionalization of amines by oxidative cross dehydrogenative coupling reaction: Simple and direct access to C-4-alkylated 3,4-dihydroquinazoline derivatives

Doi:10.1002/adsc.201200679
(2012)
Gold (I) catalysis of X-H bond insertions

Doi:10.1016/j.tetlet.2010.08.038
(2010)
Stereochemical analysis of the enzymic reduction of the double bond of α- and β-substituted nitrostyrenes and α-ethoxycinnamaldehyde through deuterium labelling experiments

Doi:10.1002/ejoc.201000442
(2010)
Tandem synthesis of tetrahydroquinolines and identification of the reaction network byoperandoNMR

Doi:10.1039/d1cy00418b
(2021)
Micellar media for the efficient ring opening of epoxides with CN^-, N₃^-, NO₃^-, NO₂^-, SCN^-, Cl^- and Br^- catalyzed with Ce(OTf)₄

Doi:10.1039/b211697a
(2003)

Article Doi