Facile synthesis of (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine an isotype-selective agonist of metabotropic glutamate receptors

DOI: 10.1016/S0040-4039(97)10037-5

Source and publish data:

Tetrahedron Letters p. 7599 - 7602 (1997)

Update date:2022-09-26

Topics:

Authors:

Ma, Dawei

Ma, Zhaochun

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Article abstract of DOI:10.1016/S0040-4039(97)10037-5

(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine (L-CCG-I) was synthesized in 12 steps and 14% overall yield by using Sharpless's asymmetric dihydroxylation reaction and stereochemically controlled cyclopropanation as key steps.

Full text of DOI:10.1016/S0040-4039(97)10037-5

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Product name:(+/-)-trans-α-(carboxycyclopropyl)glycine

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