Addition of α-Halonitriles to Carbonyl Compounds Catalyzed by Zinc-Trimethylchlorosilane: A General Synthesis of β-Trimethylsiloxy Nitriles

DOI: 10.1016/0040-4039(90)80109-Y

Source and publish data:

Tetrahedron Letters p. 2205 - 2208 (1990)

Update date:2022-07-29

Topics:

Authors:

Palomo, Claudio

Aizpurua, Jesus M.

Lopez, M. Concepcion

Aurrekoetxea, Natalia

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Article abstract of DOI:10.1016/0040-4039(90)80109-Y

Reaction between bromoacetonitrile and carbonyl compounds in the presence of zinc and trimethylchlorosilane produced β-trimethylsilyloxynitriles in excellent yields.The reaction also works well with chloroacetonitrile as source of cyanomethyl carbanion.

Full text of DOI:10.1016/0040-4039(90)80109-Y

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