Heterocycles p. 2313 - 2321 (2010)
Update date:2022-07-31
Topics:
Behbahani, Farahnaz K.
Yektanezhad, Talaye
Khorrami, Afshin R.
A simple and efficient synthesis of 2,4,5-triarylated imidazoles is achieved by three-component cyclocondensation of benzil and benzoin, aryl aldehyde and ammonium acetate using FePO4 as a catalyst in refluxing ethanol. The key advantages of this process are high yields, cost effectiveness of catalyst, easy work-up, purification of products by non-chromatographic methods and developing of a new derivative of 2,4,5-triarylated imidazole. The Japan Institute of Heterocyclic Chemistry.
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Doi:10.1021/jm101072y
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