Development of a Small RGD Peptide Fibrinogen Receptor Antagonist with Potent Antiaggregatory Activity in Vitro

DOI: 10.1021/jm00114a022

Source and publish data:

Journal of Medicinal Chemistry p. 3114 - 3125 (1991)

Update date:2022-08-04

Topics:

Authors:

Samanen, J.

Ali, F. Ali, F.

Romoff, T.

Calvo, R.

Sorenson, E.

et al. et al.

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Article abstract of DOI:10.1021/jm00114a022

The development of potent antithrombotic agents from the fibrinogen platelet receptor binding sequences Fg-α 572-575 -Arg-Gly-Asp-Ser- and Fg-γ 400-411 -HHLGGAKQAGDV, believed to be a cryptic RGD-type sequence, is described.The tetrapeptide Ac-RGDS-NH2 it

Full text of DOI:10.1021/jm00114a022

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