Journal of Organic Chemistry p. 9548 - 9560 (2019)
Update date:2022-07-30
Topics:
Feng, Juan
Zhao, Ming
Lin, Xuanzi
A novel and efficient [3 + 2] cycloaddition reaction of azaoxyallyl cations and 1,2-benzisoxazoles to give oxazoline derivatives has been developed. The transformation provides a rapid entry to functionalized oxazoline scaffolds under mild and transition-metal-free conditions, which will greatly expand the reaction types of heterocycle chemistry and pave the way for syntheses of bioactive compounds.
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