Tetrahedron p. 6211 - 6220 (1989)
Update date:2022-08-02
Topics:
Biedrzycki, Marek
Bie, Dick A. de
Plas, Henk C. van der
Thermally induced intramolecular Diels-Alder cyclisations of (alkynyloxyalkyl)pyrazines to dihydropyranopyridines have been studied in the solvent undecane.The introduction of a phenyl group in the α-position of the 3-butynyloxymethyl side chain leads to a 3-4 fold increase of the reaction rate, while the influence of a γ-phenyl group on the rate is negligible.The (3-butynyloxymethyl)pyrazine reacts about 7 times slower than the (3-propynyloxyethyl)pyrazine; the presence of a trimethylsilyl group at the terminus of the alkyne decreases in general the rate of the intramolecular cyclisation.The mechanisms are discussed.
View MoreNanjing Chemipioneer Pharma&Tech Co.,Ltd
website:http://www.chemipioneer.com.cn
Contact:+86-25-52685700
Address:Room 305,A Block,Biological-Medicine Building,Business Start-up Center,Xin-ke 1st Road, High-tech development zone,Nanjing city,Jiangsu Province, China
SHANXI JINJIN CHEMICAL INDUSTRIAL CO.,LTD
website:http://www.jinjingroup.com
Contact:4009982989
Address:Economic And Technological Development Zone,Hejin?City,Shanxi Province?,China
Shanghai Egoal Chemical Co.,Ltd
Contact:+86-21-50333091
Address:Yangming Garden Square 3,YangGao North Road 1188, Pudong New District, Shanghai
Guangzhou Flower's Song Fine Chemical CO,. Ltd
Contact:+86-20-87475199
Address:No.12, Fenghuang 3 Road, Jiulong Industrial Park, Luogang District, Guangzhou. China
Contact:18698110882
Address:1303 No2 building,LuoMa Garden,YongAn Road,Hexi District,Tianjin city
Doi:10.1002/chem.201404745
(2015)Doi:10.1248/cpb.37.1245
(1989)Doi:10.1021/ic101782v
(2011)Doi:10.1016/S0960-894X(03)00380-9
(2003)Doi:10.1021/jo102475s
(2011)Doi:10.1016/j.bmc.2013.09.067
(2013)