Studies on hindered phenols and analogues. V. Synthesis, identification and antidiabetic activity on the glucuronide of CS-045

DOI: 10.1248/cpb.39.2124

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2124 - 2125 (1991)

Update date:2022-07-29

Topics:

Authors:

Yoshioka

Aizawa Aizawa

Fujita Fujita

Nakamura

Sasahara

Kuwano Kuwano

Kinoshita

Horikoshi

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Article abstract of DOI:10.1248/cpb.39.2124

The glucuronide of a new oral antidiabetic agent, (±)-5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl]thi azolidine-2,4-dione (CS-045) (1), was synthesized to confirm the structure of a metabolite in monkeys (Macaca fassicularis) and to exa

Full text of DOI:10.1248/cpb.39.2124

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