Efficient synthesis of fluorinated α- And β-amino nitriles from fluoroalkylated α,β-unsaturated imines

Article abstract of DOI:10.1016/j.tet.2010.12.046

A simple and efficient synthesis of fluoroalkylated α-amino nitrile (4) derivatives by regioselective 1,2-addition of trimethylsilyl cyanide to fluoroalkylated α,β-unsaturated imines (1) is described. Fluoroalkylated β-amino nitriles (7) are also prepared