Synthesis and Central Nervous System Actions of Thyrotropin-Releasing Hormone Analogues Containing a Dihydroorotic Acid Moiety

DOI: 10.1021/jm00170a014

Source and publish data:

Journal of Medicinal Chemistry p. 2130 - 2137 (1990)

Update date:2022-08-05

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Authors:

Suzuki, Mamoru

Sugano, Hiroshi

Matsumoto, Kazuo

Yamamura, Michio

Ishida, Ryuichi

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Article abstract of DOI:10.1021/jm00170a014

A series of thyrotropin-releasing hormone (TRH) analogues in which the pyroglutamic acid residue was replaced by (S)-4,5-dihydroorotic acid (Dio-OH) and the related derivatives were prepared.Their central nervous system actions based on spontaneous locomo

Full text of DOI:10.1021/jm00170a014

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