
Journal of Medicinal Chemistry p. 2130 - 2137 (1990)
Update date:2022-08-05
Topics:
Suzuki, Mamoru
Sugano, Hiroshi
Matsumoto, Kazuo
Yamamura, Michio
Ishida, Ryuichi
A series of thyrotropin-releasing hormone (TRH) analogues in which the pyroglutamic acid residue was replaced by (S)-4,5-dihydroorotic acid (Dio-OH) and the related derivatives were prepared.Their central nervous system actions based on spontaneous locomo
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