Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization

Article abstract of DOI:10.1016/j.tetlet.2011.01.055

The solid-phase synthesis of sultams from resin-bound amino acids is described. The sulfonylation of the resin-bound primary amines afforded the requisite secondary amines, after which the intramolecular Buchwald-Hartwig-type coupling forms the C-S bond.