European Journal of Medicinal Chemistry p. 35 - 44 (1990)
Update date:2022-08-03
Topics:
Brunner, Henri
Hankofer, Peter
Holzinger, Ulrich
Treittinger, Barbara
Schoenenberger, Helmut
The synthesis of substituted ethylenediamines, their reactions with K2PtCl4 to give the dichloroplatinum(II) complexes, and the exchange of the chloro ligands for other leaving groups are described.The new compounds have been tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the CD2F1-mouse.In the P388 test, 53 of the 55 tested complexes fulfill the minimum activity of 125percent T/C required for a substance to be active.
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