Journal of the Chemical Society. Perkin transactions I p. 1463 - 1467 (1990)
Update date:2022-08-04
Topics:
Cornforth, John
Ming-hui, Du
The synthesis of pyrroloisoquinolinediones from phthalic anhydride and pyrrolylmagnesium halides has been improved.A new synthesis, by cyclization of the novel 1-(2-carboxybenzoyl)pyrroles, was generally preferable.From pyrrolylmagnesium bromide and dimethylmaleic anhydride, followed by cyclization, 6,7-dimethylindolizine-5,8-dione was obtained.The process failed with maleic anhydride.Pyrrolo<1,2-b>isoquinoline-5,10-dione could be dinitrated in the pyrrolo ring (with some oxidation to isoquinoline-1,3,4-trione), reduced to 10-hydroxy-3,5-dihydropyrrolo<1,2-b>isoquinolin-5-one by zinc and acetic acid, and hydrogenated over palladium on carbon to 10-hydroxy-1,2,3,5-tetrahydropyrrolo<1,2-b>isoquinolin-5-one.The dihydro derivative reverted in air to the dione.
View MoreContact:+86-710-3516804
Address:Number 83,Panggong road,Xiangcheng District,Xiangyang ,Hubei
Contact:86-575-86132822，86-575-86085355
Address:No.418 Dadao West Road,Qixing Street,Xinchang, Zhejiang Province, China.
Contact:+86-(0)21-3770 9035
Address:Room 301, Building 2, Meijiabang Road 1508, Shanghai China
Contact:+86-21-38122007
Address:2, Lane 1123, Kangqiao Road, Pudong New Area, Shanghai
Shandong Xingshun New Material Co., Ltd.
website:http://www.sd-xingshun.com
Contact:+86-519-86461196
Address:Middle of Luhua East Road, Dingtao District
Doi:10.1021/acs.joc.9b02725
(2019)Doi:10.1016/0022-328X(90)85035-W
(1990)Doi:10.1002/jlcr.1836
(2011)Doi:10.1021/ja00184a082
(1989)Doi:10.1002/chem.200900137
(2009)Doi:10.1016/S0040-4039(00)82190-5
(1988)
