Building Blocks for Oligonucleotide Analogues with Dimethylene Sulfide, Sulfoxide, and Sulfone Groups Replacing Phosphodiester Linkages

DOI: 10.1021/jo00012a018

Source and publish data:

Journal of Organic Chemistry p. 3869 - 3882 (1991)

Update date:2022-08-04

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Authors:

Huang, Zhen

Schneider, K. Christian

Benner, Steven A.

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Article abstract of DOI:10.1021/jo00012a018

Two routes are presented for the synthesis of 3',5'-bishomodeoxyribonucleosides, building blocks needed to synthesize oligodeoxynucleotide analogues where the OPO2O groups are replaced by CH2SCH2, CH2SOCH2, and CH2SO2CH2 units.Two of these have been coupl

Full text of DOI:10.1021/jo00012a018

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