Asymmetric Total Synthesis of (-)-Secodaphniphylline

DOI: 10.1021/jo00307a006

Source and publish data:

Journal of Organic Chemistry p. 5433 - 5434 (1990)

Update date:2022-08-05

Topics:

Authors:

Stafford, Jeffrey A.

Heathcock, Clayton H.

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Article abstract of DOI:10.1021/jo00307a006

An asymmetric total synthesis of (-)-secodaphniphyllin (5) is described.The desired absolute stereochemistry is established in two stereoselective transformations - an asymmetric Michael reaction of amide 8 and an asymmetric reduction of ketone 14.

Full text of DOI:10.1021/jo00307a006

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Product name:Methyl <2S-<1*<1R^*,1(E),2S^*>>,2α,5β>>-1-(4,8-Dimethyl-3,7-nonadienyl)-2-<1-<(2,5-dimethyl-1-pyrrolidinyl)carbonyl>-4-(phenylmethoxy)butyl>cyclopentanecarboxylate

Cas No:129539-97-5

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