Long-acting dihydropyridine calcium antagonists. 6. Structure-activity relationships around 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-2-[(2-hydroxyethoxy) methyl]-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

DOI: 10.1021/jm00105a004

Source and publish data:

Journal of Medicinal Chemistry p. 19 - 24 (1991)

Update date:2022-08-05

Topics: Structure-activity relationships

Authors:

Alker Alker

Campbell

Cross Cross

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Article abstract of DOI:10.1021/jm00105a004

The preparation of 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-2-[(2-hydroxyethoxy) methyl]-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyrimidine (2) is described, and its potent calcium antagonist activity on rat aorta (IC₅₀ = 4 x 10^-9 M

Full text of DOI:10.1021/jm00105a004

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