Long-acting dihydropyridine calcium antagonists. 6. Structure-activity relationships around 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-2-[(2-hydroxyethoxy) methyl]-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

DOI: 10.1021/jm00105a004

Source and publish data:

Journal of Medicinal Chemistry p. 19 - 24 (1991)

Update date:2022-08-05

Topics: Structure-activity relationships

Authors:

Alker Alker

Campbell

Cross Cross

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00105a004

The preparation of 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-2-[(2-hydroxyethoxy) methyl]-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyrimidine (2) is described, and its potent calcium antagonist activity on rat aorta (IC₅₀ = 4 x 10^-9 M

Full text of DOI:10.1021/jm00105a004

Products guided by the article

Product name:3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2-methyl-6-(propoxymethyl)-, 5-ethyl 3-methyl ester

Cas No:130574-76-4

R&D Labs maybe for 130574-76-4

Shanghai Taibao Pharmaceutical Technology Co., Ltd(expird)

Contact:021-52217366

Address:shanghai
Changsha Nutritopper Bio Technology Co.,Ltd.

Contact:+86-731-87803543

Address:East 1st Street, Baima Road, Ningxiang County
Zhengzhou Minzhong Pharmaceutical Co.,ltd

Contact:0086-371-65797115

Address:15/F,Jiangshan Bldg, NO.126 Huanghe Road,Zhengzhou, China
Shanghai Forever Synthesis Co.,Ltd.

Contact:021-61124658

Address:Zhoukang Road,Pudong New District,Shanghai,China
WENZHOU M&C FOREIGN TRADE CO.,LTD.

Contact:+86-577-88862917

Address:No.8 Liming West Road,Wenzhou,zhejiang,China

Relevant to this article

A Diels-Alder approach to Stemona alkaloids: Total synthesis of stenine

Doi:10.1021/jo00067a015
(1993)
Multihydroxyl-functional polystyrenes in continuous flow

Doi:10.1021/ma902849r
(2010)
BASIC HYDROLYSIS OF 3-ACETOXY-7-BROMO-5-(o-CHLOROPHENYL)-1-ETHOXYCARBONYLMETHYL-1,2-DIHYDRO-3H-1,4-BENZDIAZEPIN-2-ONE

Doi:10.1007/BF00487438
(1990)
REACTION OF 9-DIAZO-4-AZAFLUORENE WITH UNSATURATED COMPOUNDS AND CYCLIC KETONES

Doi:10.1007/BF00497215
(1990)
FIRST SYNTHESIS OF ALPHA GLUCOSINOLATES

Doi:10.1016/S0040-4039(00)97490-2
(1990)
Discovery of fluorescent cyanopyridine and deazalumazine dyes using small molecule macroarrays

Doi:10.1021/ol0602708
(2006)

Article Doi