Journal of Medicinal Chemistry p. 19 - 24 (1991)
Update date:2022-08-05
Topics: Structure-activity relationships
Alker
Campbell
Cross
The preparation of 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-2-[(2-hydroxyethoxy) methyl]-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyrimidine (2) is described, and its potent calcium antagonist activity on rat aorta (IC50 = 4 x 10-9 M
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