
Heterocycles p. 215 - 220 (1997)
Update date:2022-09-26
Topics:
Hashimoto, Shun-Ichi
Inagaki, Jun
Sakamoto, Hiroki
Sano, Ai
Nakajima, Makoto
A facile and direct method for the construction of 2′-deoxy-β-N-glycosidic linkages in 2′-deoxyribonucleoside synthesis has been developed by using 3-(3,4,5-trimethoxybenzoyl)-protected 2-deoxyribofuranosyl diethyl phosphites as a glycosyl donor in the presence of trimethylsilyl triflate, wherein coupling reactions with silylated pyrimidine bases have been found to exhibit β-selectivities up to 96%.
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