PERFLUOROALKYL AND PERFLUOROALKYLETHER CHLOROSULFATES IN THE SYNTHESIS OF SUBSTITUTED BENZAZOLES

Article abstract of DOI:10.1016/S0022-1139(00)80379-6

Perfluoroalkyl and perfluoroalkylehter chlorosulfates prepared from correspondign iodides have been utilized in the synthesis of 2-substituted benzoxazoles, benzthiazoles and benzimidazoles.The chlorosulfates react readily with the appropriate 2-hydroxy, 2-mercapto and 2-aminoanilines at or below ambient temperatures.The products are a mixture of the heterocyclic compounds and their precursor anilides except in the case of 2-hydroxyaniline, which gives only the anilide.The initial products obtained are readily converted to the heterocyclic compounds in fair to high yields.