Preparations of antifungal Sch 42427/SM 9164: Preparative chromatographic resolution, and total asymmetric synthesis via enzymatic preparation of chiral α-hydroxy arylketones

DOI: 10.1016/0040-4039(95)02234-1

Source and publish data:

Tetrahedron Letters p. 611 - 614 (1996)

Update date:2022-08-05

Topics: Total asymmetric synthesis Enzymatic preparation

Authors:

Gala, Dinesh

DiBenedetto, Donald J.

Clark, Jon E.

Murphy, Bruce L.

Schumacher, Doris P.

Steinman, Martin

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Article abstract of DOI:10.1016/0040-4039(95)02234-1

Efficient approaches towards the preparation of chiral azole antifungals Sch 42427/SM 9164 (1) via large scale chromatographic separation of its enantiomers, or via enzymatic syntheses of key chiral intermediates α-hydroxy arylketones 5 in excellent enantiomeric excesses (ees) are described.

Full text of DOI:10.1016/0040-4039(95)02234-1

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