Preparations of antifungal Sch 42427/SM 9164: Preparative chromatographic resolution, and total asymmetric synthesis via enzymatic preparation of chiral α-hydroxy arylketones

DOI: 10.1016/0040-4039(95)02234-1

Source and publish data:

Tetrahedron Letters p. 611 - 614 (1996)

Update date:2022-08-05

Topics: Total asymmetric synthesis Enzymatic preparation

Authors:

Gala, Dinesh

DiBenedetto, Donald J.

Clark, Jon E.

Murphy, Bruce L.

Schumacher, Doris P.

Steinman, Martin

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(95)02234-1

Efficient approaches towards the preparation of chiral azole antifungals Sch 42427/SM 9164 (1) via large scale chromatographic separation of its enantiomers, or via enzymatic syntheses of key chiral intermediates α-hydroxy arylketones 5 in excellent enantiomeric excesses (ees) are described.

Full text of DOI:10.1016/0040-4039(95)02234-1

Products guided by the article

Product name:1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one

Cas No:132563-81-6

R&D Labs maybe for 132563-81-6

ENERGYCO LTD.

Contact:+86-25-83719363

Address:106-7 Chunnan Rd, Chunxi Town, Gaochun, Nanjing, China
Nanjing distinctions Medical Technology Co., Ltd.(expird)

Contact:+86-15996203785 13914714059

Address:nanjing,jiangsu , China
Dalian Join King Biochemical Tech. Co., Ltd.

Contact:0411 39216206

Address:814 First State Blvd
Shanghai Longjin Metallic Material Co., Ltd.

website:http://www.shlongjin.cn/

Contact:021-56517503,56502257

Address:No.16, Lane 555, Chengyin Road, Shanghai
Chemsigma International Co.,Ltd.

website:http://www.chemsigma.com

Contact:86-025-58748998

Address:Rm.705, 15th Building,Rd.Xinke II

Relevant to this article

Stereocontrolled synthesis of 6-s-cis- and 6-s-trans-locked 9Z-retinoids by hydroxyl-accelerated Stille coupling of (Z)-tri-n-butylstannylbut-2-en-1-ol and bicyclic dienyl triflates

Doi:10.1021/jo9917588
(2000)
Doi:10.1021/ja01566a032
(1957)
C-Aryl glucosides substituted at the 4′-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

Doi:10.1016/j.bmcl.2011.06.032
(2011)
Coniferyl alcohol metabolism in conifers - I. Glucosidic turnover of cinnamyl aldehydes by UDPG: Coniferyl alcohol glucosyltransferase from pine cambium

Doi:10.1016/S0031-9422(01)00107-8
(2001)
Studies on (H⁺-K⁺)-ATPase Inhibitors of Gastric Acid Secretion. Prodrugs of 2-<(2-Pyridinylmethyl)sulfinyl>benzimidazole Proton-Pump Inhibitors

Doi:10.1021/jm00107a026
(1991)
Doi:10.1080/08037060121425
(1958)

Article Doi