Benzyloxazolidine-2,4-diones as potent hypoglycemic agents

DOI: 10.1021/jm00109a003

Source and publish data:

Journal of Medicinal Chemistry p. 1538 - 1544 (1991)

Update date:2022-09-26

Topics:

Authors:

Dow Dow

Bechle Bechle

Chou Chou

Clark Clark

Hulin Hulin

Stevenson

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Article abstract of DOI:10.1021/jm00109a003

A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.

Full text of DOI:10.1021/jm00109a003

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