Journal of Medicinal Chemistry p. 2095 - 2103 (1992)
Update date:2022-08-06
Topics:
Sliskovic
Blankley
Krause
Newton
Picard
Roark
Roth
Sekerke
Shaw
Stanfield
A series of N-heteroaryl-substituted mevalonolactones were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase both in vitro and in vivo, and to lower plasma cholesterol in a hypercholesterolemic dog model. The goal of the str
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(1990)