Synthesis of α-Ketols Mediated by Divalent Samarium Compounds

DOI: 10.1021/jo00009a035

Source and publish data:

Journal of Organic Chemistry p. 3118 - 3122 (1991)

Update date:2022-08-03

Topics:

Authors:

Collin, Jacqueline

Namy, Jean-Louis

Dallemer, Frederic

Kagan, Henri B.

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Article abstract of DOI:10.1021/jo00009a035

Coupling reactions of acid chlorides are mediated by SmI2 and SmCp2, leading to α-ketols 3.Condensation reactions of acid chlorides on aldehydes similarly product α-ketols 5; with ketones, best results are obtained with use of SmI2.Reactivities of SmI2 and SmCp2 are compared and mechanisms of the reactions discussed.Formation of an acylsamarium species is shown.

Full text of DOI:10.1021/jo00009a035

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