New peptidyl-anthraquinones: Synthesis and DNA binding

Article abstract of DOI:10.1080/07328319808004756

Aminoacyl-hydroxy-anthraquinones bearing glicyl, valyl, lysyl and tryptophanyl residues in the side-chain were synthesized as new potential DNA-directed drugs. These compounds bind very tightly to double-stranded DNA by intercalating their planar portion into the nucleic acid and further stabilizing the complex through electrostatic contacts with the backbone phosphates. All protonated groups in the side-chains participate in the latter process. The free energy of DNA-binding corrected for the electrostatic contribution is similar for the lysyl and glicyl derivatives, which points to a common geometry of intercalation.

Full text of DOI:10.1080/07328319808004756

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Nucleosides and Nucleotides
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New Peptidyl-Anthraquinones: Synthesis
and DNA Binding
Giuseppe. Zagotto a , Giovanni. Mitaritonna a , Claudia. Sissi a &
Manlio. Palumbo a
a Department of Pharmaceutical Sciences , University of Padova , Via
Marzolo 5, 35131, Padova, Italy
Published online: 22 Aug 2006.
To cite this article: Giuseppe. Zagotto , Giovanni. Mitaritonna , Claudia. Sissi & Manlio. Palumbo
(1998) New Peptidyl-Anthraquinones: Synthesis and DNA Binding, Nucleosides and Nucleotides, 17:9-11,
2135-2141, DOI: 10.1080/07328319808004756
To link to this article: http://dx.doi.org/10.1080/07328319808004756
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