Preparation and anticonvulsant activity of a series of functionalized α-heteroatom-substituted amino acids

Article abstract of DOI:10.1021/jm00112a020

Potent anticonvulsant activity has been reported for (R,S)-2-acetamido-N-benzyl-2-methylacetamide (2a). Select α-heteroatom substituted derivatives of 2a have been prepared (26 examples) in which the α-methyl group has been replaced by nitrogen (3a-q), ox