Syntheses of 5,7,8- and 5,6,7-Trioxygenated 3-Alkyl-3',4'-dihydroxyflavones and Their Inhibitory Activities against Arachidonate 5-Lipoxygenase

Article abstract of DOI:10.1021/jm00111a037

5,6,7- and 5,7,8-Trioxygenated 3',4'-dihydroxyflavones were derivatized by introducing alkyl groups of various chain lengths at the 3-position of the flavone skeleton.These compounds were tested as inhibitors for arachidonate 5-lipoxygenase purified from