Bioorganic and Medicinal Chemistry Letters p. 6788 - 6792 (2011)
Update date:2022-08-05
Topics:
Zhang, Hong-Wang
Zhou, Longhu
Coats, Steven J.
McBrayer, Tamara R.
Tharnish, Phillip M.
Bondada, Lavanya
Detorio, Mervi
Amichai, Sarah A.
Johns, Melissa D.
Whitaker, Tony
Schinazi, Raymond F.
Based on the anti-hepatitis C activity of 2′-C-methyl-adenosine and 2′-C-methyl-guanosine, a series of new modified purine 2′-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified
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