European Journal of Medicinal Chemistry p. 79 - 84 (1991)
Update date:2022-09-26
Topics:
Menager
Loire
Lafont
Champeyrol
Delabos
Garnier
Combet Farnoux
These compounds were synthesised, via a double Mannich reaction between 5,5-diethyl-4-iminobarbituric acid, formaldehyde and primary chlorophenylamines. The by-products of the reaction, 1,3,5,-triarylhexahydro-s-triazines and monoamino-methylpyrimidinediones, were identified and their formation discussed. It was shown that the extracyclic nitrogen atom underwent the first aminomethylation and that the substitution of the intracyclic nitrogen atom, inducing ring closure, took place in a second step. All the compounds exhibited antimicrobial activities against bacteria and/or fungi and the derivative presenting a chlorine atom in the 3-position on the nucleus was as active as miconazole nitrate agonist T rubrum and E floccosum.
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