New Chiral Auxiliaries Derived from β-Pinene: Their Use in the Asymmetric Reduction of β-Keto-Esters

Article abstract of DOI:10.1016/S0957-4166(00)82117-5

3-Ketobutyrates 6, derived from chiral auxiliary alcohols 5 - themselves efficiently prepared from β-pinene 4 - were reduced with zinc borohydride, giving 3-hydroxybutyrates 7 with 2-70percent de, depending on the nature of aryl group in alcohols 5.