Evaluation of the thiosemicarbazones of some aryl alkyl ketones and related compounds for anticonvulsant activities

Article abstract of DOI:10.1016/0223-5234(91)90148-G

The thiosemicarbazone of acetophenone (1a) had been shown previously to afford protection against experimentally-induced seizures.This report describes the systematic chemical modification of 1a and the activities of these analogues in the maximal electro