Synthesis, cardiac electrophysiology, and β-blocking activity of novel arylpiperazines with potential as class II/III antiarrhythmic agents

Article abstract of DOI:10.1021/jm00082a016

A series of novel arylpiperazines have been prepared in an attempt to incorporate both class II (β-receptor blocking) and class III antiarrhythmic properties in a single molecule. The key step in the preparation of the new compounds involves a regioselect