Synthesis of lipophilic phosphate triester derivatives of 5-fluorouridine and arabinocytidine as anticancer prodrugs

DOI: 10.1016/0040-4039(91)80219-V

Source and publish data:

Tetrahedron Letters p. 6553 - 6556 (1991)

Update date:2022-07-29

Topics:

Authors:

Le Bec Le Bec

Huynh-Dinh

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(91)80219-V

The phosphoramidite method was applied for the preparation of phosphotriesters of anticancer nucleosides. By this way, derivatives of 5-fluorouridine (5-FU) and arabinofuranosylcytidine (ara-C) were synthesized as possible membrane anchored prodrugs.

Full text of DOI:10.1016/0040-4039(91)80219-V

Products guided by the article

Product name:C₄₀H₄₁FN₃O₂₀P

Cas No:138493-80-8

R&D Labs maybe for 138493-80-8

Nanjing HuiBaiShi Biotechnology Co.,Ltd.

Contact:+86 (25)58745219

Address:No.606 Ningliu Road,LiuHe District.
Kono Chem Co.,Ltd

website:http://www.konochem.com

Contact:86-29-86107037

Address:No.170 West Avenue,Xi’an 710082,China
chengdu firsterchem Pharmaceutical Co., Ltd.

Contact:028-66825849

Address:chengdu
kern enterprises

Contact:+86-13236304423

Address:heping street NO.828,weifang city,shandong province,china
Shenzhen ZheYi Chemicals Co.,LTD(Shanghai Branch)

Contact:+86-21-54159691

Address:Room1002,Building No.2, Lane 98 Bixiu Road,Minhang District, Shanghai,China 201100

Relevant to this article

The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity

Doi:10.1016/j.bmcl.2012.04.118
(2012)
A NEW SYNTHESIS OF OPTICALLY ACTIVE β-MERCAPTOCARBOXYLIC ACID ESTERS

Doi:10.1016/S0040-4039(00)93586-X
(1991)
Metalloporphyrin as a ligand in organometallic complexes: Synthesis and characterization of a nickel(II) porphyrin complex of 1,5- cyclooctadienedichlororuthenium(II)

Doi:10.1016/j.jorganchem.2005.07.030
(2005)
Synthesis, cytotoxic evaluation, docking and in silico pharmacokinetic prediction of 4-arylideneamino/cycloalkylidineamino 1, 2-naphthoquinone thiosemicarbazones

Doi:10.3109/14756366.2012.721783
(2013)
Oxidative aryl-aryl, aryl-benzyl coupling of lignans-reactions of phyllanthin and haloderivatives with TTFA, DDQ, Li/THF)))): Synthesis of dibenzocyclooctadiene system and phyltetralin

Doi:10.1016/S0040-4020(01)91020-8
(1991)
New alkoxypyridine-sulfonamides: Synthesis, biological evaluation, and physicochemical properties

Doi:10.1002/hlca.19910740819
(1991)

Article Doi