Synthesis of lipophilic phosphate triester derivatives of 5-fluorouridine and arabinocytidine as anticancer prodrugs

DOI: 10.1016/0040-4039(91)80219-V

Source and publish data:

Tetrahedron Letters p. 6553 - 6556 (1991)

Update date:2022-07-29

Topics:

Authors:

Le Bec Le Bec

Huynh-Dinh

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Article abstract of DOI:10.1016/0040-4039(91)80219-V

The phosphoramidite method was applied for the preparation of phosphotriesters of anticancer nucleosides. By this way, derivatives of 5-fluorouridine (5-FU) and arabinofuranosylcytidine (ara-C) were synthesized as possible membrane anchored prodrugs.

Full text of DOI:10.1016/0040-4039(91)80219-V

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