Synthesis of lipophilic phosphate triester derivatives of 5-fluorouridine and arabinocytidine as anticancer prodrugs

Article abstract of DOI:10.1016/0040-4039(91)80219-V

The phosphoramidite method was applied for the preparation of phosphotriesters of anticancer nucleosides. By this way, derivatives of 5-fluorouridine (5-FU) and arabinofuranosylcytidine (ara-C) were synthesized as possible membrane anchored prodrugs.