Journal of Medicinal Chemistry p. 1267 - 1272 (1992)
Update date:2022-09-26
Topics:
Shaw, Kenneth J.
Erhardt, Paul W.
Hagedorn, Alfred A.
Pease, Cynthia A.
Ingebretsen, William R.
Wiggins, Jay R.
The cardiotonic agent 4-ethyl-1,3-dihydro-5-<4-(2-methyl-1H-imidazol-1-yl)benzoyl>-2H-imidazol-2-one (1) was found to have low bioavailability when administered orally to rats and dogs.A series of N-acyl derivatives, an underutilized prodrug of acidic NH
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