Cardiotonic Agents. 7. Prodrug Derivatives Of 4-Ethyl-1,3-dihydro-5--2H-imidazol-2-one

DOI: 10.1021/jm00085a014

Source and publish data:

Journal of Medicinal Chemistry p. 1267 - 1272 (1992)

Update date:2022-09-26

Topics:

Authors:

Shaw, Kenneth J.

Erhardt, Paul W.

Hagedorn, Alfred A.

Pease, Cynthia A.

Ingebretsen, William R.

Wiggins, Jay R.

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Article abstract of DOI:10.1021/jm00085a014

The cardiotonic agent 4-ethyl-1,3-dihydro-5-<4-(2-methyl-1H-imidazol-1-yl)benzoyl>-2H-imidazol-2-one (1) was found to have low bioavailability when administered orally to rats and dogs.A series of N-acyl derivatives, an underutilized prodrug of acidic NH

Full text of DOI:10.1021/jm00085a014

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Product name:2H-Imidazol-2-one, 4-ethyl-5-(4-fluorobenzoyl)-1,3-dihydro-1,3-bis(phenylmethyl)-

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