Chemistry Letters p. 305 - 308 (1992)
Update date:2022-08-04
Topics:
Lawrence, Ronnie
Perlmutter, Patrick
In this paper we show that the stabilized carbanion dimethyl malonate adds to alkyl 2-(1-hydroxyalkyl)propenoates under basic conditions.Side reactions, such as lactonization or elimination, may be reduced and/or completely avoided by the use of phase transfer catalysis.The high stereoselctivity associated with the additions discussed here was found to be under thermodynamic control.
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Doi:10.1021/jo00037a052
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