Synthesis of 1,2,4-triazines. XII. New synthesis of 1,2,4-triazines with a functional group in the 6-position

Article abstract of DOI:10.1016/S0040-4020(01)88125-4

6-Acyl- (15, 17) and 6-ethoxycarbonyl-5-substituted 1,2,4-triazines (11) were prepared by refluxing acylhydrazones (10, 14) or N,N-dimethylaminomethylenehydrazones (16) with ammonium acetate in acetic acid. NMR-studies confirmed the high regio selectivity