The total synthesis of swinholide A. Part 2: A stereocontrolled synthesis of a C1-C15 segment

DOI: 10.1016/0040-4020(95)00547-L

Source and publish data:

Tetrahedron p. 9413 - 9436 (1995)

Update date:2022-07-30

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Authors:

Paterson

Smith Smith

Ward Ward

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Article abstract of DOI:10.1016/0040-4020(95)00547-L

The C₁-C₁₅ segment 3 of swinholide A was prepared in 10 steps (14% yield) from the methyl ketone 13. Key steps include (i) the asymmetric aldol reaction, 13 → 35, followed by cyclisation to give the dihydropyrone 36, (ii) the Ferrier

Full text of DOI:10.1016/0040-4020(95)00547-L

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