Orally Active Aldose Reductase Inhibitors: Indazoleacetic, Oxopyridazineacetic, and Oxopyridopyridazineacetic Acid Derivatives

DOI: 10.1021/jm00090a002

Source and publish data:

Journal of Medicinal Chemistry p. 2155 - 2162 (1992)

Update date:2022-07-30

Topics:

Authors:

Mylari, Banavara L.

Zembrowski, William J.

Beyer, Thomas A.

Aldinger, Charles E.

Siegel, Todd W.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00090a002

Benzothiazole side chains featured in zopolrestat (1a) and its congeners were incorporated into oxophthalazineacetic acid replacements, including indazole, pyridazinone, and pyridopyridazinone with a pendant acetic acid moiety.Potent aldose reductase inhi

Full text of DOI:10.1021/jm00090a002

Products guided by the article

Product name:Benzo[g]phthalazine-1-acetic acid, 3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-, ethyl ester

Cas No:140926-39-2

R&D Labs maybe for 140926-39-2

Shanghai Intime pharm Co.,Ltd

Contact:86-21-58226973

Address:No 351,Guoshoujing Road, Zhangjiang Hi-tech Park, Pudong, Shanghai, China
Chengdu Push Bio-technology Co., Ltd

Contact:--

Address:No.8 Wuke West Second Road, Wuhou
N&R INDUSTRIES,INC

Contact:Tel:+86-29-88764861 Fax:+86-29-88764861

Address:Rm#2107, Block A, Epin Meidao Building, Gaoxin Rd, Hi-Tech Zone, Xi’an, China
Zouping Mingxing Chemical Co.,Ltd.

website:http://www.zoutong.com.cn

Contact:86-543-2240068 2240067

Address:428 Daixi Third Road Zouping County Shandong Province China
Beijing Green Guardee Technology CO,.LTD

Contact:+86-10-69706062

Address:F2 BLdj,5 No.37 Chaoqian Road

Relevant to this article

O-Perhalopyridin-4-yl Hydroxylamines: Amidyl-Radical Generation Scaffolds in Photoinduced Direct Amination of Heterocycles

Doi:10.1021/acs.orglett.1c00064
(2021)
A combined experimental and computational study of the substituent effect on micellar behavior of γ-substituted thermoresponsive amphiphilic poly(ε-caprolactone)s

Doi:10.1021/ma400855z
(2013)
UTILISATION DE MEMBRANES ECHANGEUSES D'IONS EN ELECTROSYNTHESE ORGANIQUE.

Doi:10.1016/S0040-4020(01)87706-1
(1987)
Palladium-catalyzed arylic/allylic aminations: Permutable domino sequences for the synthesis of dihydroquinolines from morita-baylis-hillman adducts

Doi:10.1021/ol401234v
(2013)
PIDA-promoted intramolecular transannular aziridination to synthesize bridged azatricyclic amines related to methyllycaconitine

Doi:10.1016/j.tet.2013.04.102
(2013)
Conformation and atropisomeric properties of indometacin derivatives

Doi:10.1002/chem.201300064
(2013)

Article Doi