Orally Active Aldose Reductase Inhibitors: Indazoleacetic, Oxopyridazineacetic, and Oxopyridopyridazineacetic Acid Derivatives

DOI: 10.1021/jm00090a002

Source and publish data:

Journal of Medicinal Chemistry p. 2155 - 2162 (1992)

Update date:2022-07-30

Topics:

Authors:

Mylari, Banavara L.

Zembrowski, William J.

Beyer, Thomas A.

Aldinger, Charles E.

Siegel, Todd W.

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Article abstract of DOI:10.1021/jm00090a002

Benzothiazole side chains featured in zopolrestat (1a) and its congeners were incorporated into oxophthalazineacetic acid replacements, including indazole, pyridazinone, and pyridopyridazinone with a pendant acetic acid moiety.Potent aldose reductase inhi

Full text of DOI:10.1021/jm00090a002

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Product name:Benzo[g]phthalazine-1-acetic acid, 3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-, ethyl ester

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