AN EFFICIENT PARTIAL SYNTHESIS OF (+)-ARTEMISININ AND (+)-DEOXOARTEMISININ

Article abstract of DOI:10.1016/S0040-4039(00)91851-3

Arteannuic acid and arteannuin B are separately convertible into intermediate 8, which is transformed by four of five high-yielding steps into the title anti-malarial sesquiterpene peroxides. Key Words: Artemisinin, Deoxoartemisinin, Arteannuin B, Arteannuic Acid, Singlet Oxygen, Reducitive Elimination, Ketalization, Allylic Oxidation.