Design, synthesis, and evaluation of potent novel peroxisome proliferator-activated receptor γ indole partial agonists

DOI: 10.1016/j.bmcl.2019.126664

Source and publish data:

Bioorganic and Medicinal Chemistry Letters (2019)

Update date:2022-08-05

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Authors:

Eeda, Venkateswararao

Wu, Dan Wu, Dan

Lim, Hui-Ying

Wang, Weidong

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Article abstract of DOI:10.1016/j.bmcl.2019.126664

Peroxisome Proliferator-Activated Receptor γ (PPARγ) is a nuclear receptor important for glucose homeostasis and insulin sensitivity. The anti-diabetic drugs thiazolidinediones improve insulin sensitivity by blocking PPARγ phosphorylation at S273; however

Full text of DOI:10.1016/j.bmcl.2019.126664

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